An estimated 50,000 teachers, 10,000 schools/sites, and 3 million students have participated in the LifeSkills Training program. The duration of implementation varies; some sites have implemented LST for 5 years or longer. LST has been extensively evaluated in more than 30 scientific studies involving more than 330 schools/sites and 26,000 students in suburban, urban, and rural settings.

LST has been used with youth in all 50 states in the United States as well as in the District of Columbia, Puerto Rico, and the Virgin Islands. Outside the United States, it has been used in 33 countries including Australia, Bermuda, Canada, Croatia, Denmark, England, France, Germany, Greece, Honduras, Hong Kong, Ireland, Italy, Japan, Kenya, Malaysia, Mexico, New Zealand, Nicaragua, Norway, Panama, Portugal, Qatar, Russia, Saudi Arabia, South Africa, South Korea, Spain, Sweden, Taiwan, Thailand, Turkey, and Venezuela.